Renal Endothelial Dysfunction in Acute Kidney Ischemia Reperfusion Injury
نویسندگان
چکیده
منابع مشابه
Renal endothelial dysfunction in acute kidney ischemia reperfusion injury.
Acute kidney injury is associated with alterations in vascular tone that contribute to an overall reduction in GFR. Studies in animal models indicate that ischemia triggers alterations in endothelial function that contribute significantly to the overall degree and severity of a kidney injury. Putative mediators of vasoconstriction that may contribute to the initial loss of renal blood flow and ...
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TLRs are conserved pattern recognition receptors that detect motifs of pathogens and host material released during injury. For unknown reasons, renal TLR2 mRNA is mainly expressed by tubular cells and is enhanced upon renal ischemia/reperfusion (I/R) injury. We evaluated the role of TLR2 in I/R injury using TLR2-/- and TLR2+/+ mice, TLR2 antisense oligonucleotides, and chimeric mice deficient i...
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ژورنال
عنوان ژورنال: Cardiovascular & Hematological Disorders-Drug Targets
سال: 2014
ISSN: 1871-529X
DOI: 10.2174/1871529x1401140724093505